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My top ten would be...
I think Sidney Poitier basically killed his career makings sequels to In the Heat of the Night. I doubt anyone on this board even watched them.
The Pink Panther also should have stayed as a one and done.
Police Academy I can understand why they kept it going but I think the film would have been fondly remembered as a one and done and not as a joke of a franchise.
Speed was the absolute worst sequel I think I've ever seen.
The Ring really haven't been impressed with either the US or Japanese attempts at sequels/prequels.
Ant-Man, I liked both sequels to Ant-man but the first worked as a standalone and a number of concepts and ideas were just wasted in the sequels.
Captain Marvel, unlike the Ant-man sequels I understand that they had to do another one but oof was that a stinker.
Battle Royale, the ideas weren't there for a sequel.
The Exorcist, I adore III but one of the worst managed franchises in history in my eyes.
Friday, comedy sequels are never good. I think if it were just left alone it would be considered a classic to everyone.